Qualys vs SentinelOne: Complete Comparison (2026)
In comparing Qualys and SentinelOne in 2026, SentinelOne is the stronger choice for enterprises wanting ai-driven autonomous endpoint protection and response due to autonomous threat response. Qualys excels for enterprise security teams needing comprehensive vulnerability and compliance scanning with comprehensive vulnerability management. Qualys offers Vulnerability scanning, Compliance monitoring, Asset inventory starting at Custom pricing. SentinelOne provides AI-powered endpoint protection, Autonomous response, EDR from $45/endpoint/yr. For teams prioritizing value, SentinelOne delivers a hiltonsoftware Score of 69/100. Qualys and SentinelOne compete in the cybersecurity segment of the SaaS market, where cloud-native solutions, API integrations, and workflow automation drive enterprise and SMB adoption. Other leading cybersecurity tools include Okta, 1Password, Cloudflare. Qualys serves 10K+ orgs users globally (founded 1999) while SentinelOne reports 12K+ orgs active users (founded 2013).
Qualys vs SentinelOne at a Glance
What are the main differences between Qualys and SentinelOne?
Qualys and SentinelOne differ across ease of use, features, value, support, integrations, scalability, and learning curve. SentinelOne leads in 7 of 7 categories.
What are the pros and cons of Qualys vs SentinelOne?
Which is better, Qualys or SentinelOne?
After evaluating Qualys and SentinelOne across features, pricing, integrations, and user satisfaction, SentinelOne earns a higher hiltonsoftware Score of 69/100 versus Qualys at 65/100. SentinelOne stands out for "autonomous threat response" and "excellent edr capabilities". Qualys delivers competitive advantages in "comprehensive vulnerability management", making Qualys a viable alternative.
Neither Qualys nor SentinelOne offers a free plan. Qualys starts at Custom pricing and SentinelOne at $45/endpoint/yr.
Bottom line: Choose Qualys for enterprise security teams needing comprehensive vulnerability and compliance scanning. Choose SentinelOne for enterprises wanting ai-driven autonomous endpoint protection and response. Both Qualys and SentinelOne are established cybersecurity platforms.
Enterprise security teams needing comprehensive vulnerability and compliance scanning.
Enterprises wanting AI-driven autonomous endpoint protection and response.
Qualys vs SentinelOne: Frequently Asked Questions
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Reviewed by Elena Kowalski, Security & Enterprise Editor. Last updated: 2026-04-24. Pricing verified: March 2026.
Read our scoring methodology to understand how the hiltonsoftware Score is calculated.